Antitumor/antiviral drugs target on STING

WHO admits its target on AIDS drugs may be unrealistic.

Prediction of Drugs Target Groups Based on ChEBI Ontology

Most drugs have beneficial as well as adverse effects and exert their biological functions by adjusting and altering the functions of their target proteins. Thus, knowledge of drugs target proteins is essential for the improvement of therapeutic effects and mitigation of undesirable side effects. In the study, we proposed a novel prediction method based on drug/compound ontology information ext...

Sting fever

On August 17, The editors at USA Today had a tough call to make — whether to lead the paper with the fact that Elvis Presley has been dead for 25 years — or go with the story about the exotic virus sweeping west faster than wildfires. Anxiety won out over nostalgia, with Elvis relegated to the cover story in the Weekend section. 'West Nile outbreak expected to worsen,' read the top headline in ...

Linn) sting extract on experimental animals

A sting of the fish S. argus, a venomous edible spotted butterfish, produces tremendous local pain, severe swelling, rise of body temperature, throbbing sensation etc. To establish the pharmacological activities of S. argus sting extract, the present investigation, was carried out on experimental animals. The LDso of extract was found to be 9.3 mg/kg (iv) in male albino mice. The extract showed...

TAFI: A Potential Target for Fibrinolytic Drugs

Thrombosis is one the major cause of death worldwide. Clinicians and haematologists are confronted more and more with diagnosis and management of patients with venous and arterial thrombo-embolic phenomenon. In the recent past there have been major advancements in the field of the aetio-pathogenisis of haemostasis. Thrombosis occurs when there is an imbalance between pro-thrombotic and anti-thr...